Fecal microbiota transplantation (FMT) has gained popularity as an effective therapeutic option for infection (CDI). Since its FDA recognition as a treatment modality for recurrent CDI in 2013, screening protocols for FMT donor stool have been in flux. However, extensive health questionnaires, in combination with serological and stool assays, have become mainstays in the donor screening process, although ethical implications are yet to be thoroughly considered. Herein, we present the case of a family member found to have a false-positive HIV test during the donor screening process and discuss potential ethical ramifications associated with FMT stool donation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668332PMC
http://dx.doi.org/10.1155/2021/6696542DOI Listing

Publication Analysis

Top Keywords

ethical implications
8
fecal microbiota
8
microbiota transplantation
8
false-positive hiv
8
hiv test
8
donor screening
8
screening process
8
implications fecal
4
transplantation disclosure
4
disclosure false-positive
4

Similar Publications

Background: The distribution of hosts and parasitoids across patches is a key factor determining the dynamics of host-parasitoid populations. To connect behavioral rules with population dynamics, it is essential to comprehend how individual-level dispersal behavior influences the distribution of individuals. Typically, a simple deterministic model has been used to describe this connection.

View Article and Find Full Text PDF

Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a zoonotic pathogen that poses a serious threat to veterinary and public health worldwide. We investigated mastitis milk samples for contamination with MRSA and also characterized the MRSA isolates by investigating antimicrobial resistance and virulence factors.

Result: We confirmed MRSA in 69 of 201 (34.

View Article and Find Full Text PDF

Sex differences in disease: sex chromosome and immunity.

J Transl Med

December 2024

The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, 730000, China.

Sex is a fundamental biological variable that influences immune system function, with sex chromosomes (X and Y) playing a central role in these differences. Despite substantial evidence of disparities in immune responses between males and females, biomedical research has historically overlooked sex as a critical factor. This oversight has contributed to the observed disparities in susceptibility to autoimmune diseases, infectious diseases, and malignancies between the sexes.

View Article and Find Full Text PDF

The lysine-specific demethylase 5 (KDM5) family, a key post-translational modification of chromatin, can shape tumor immune microenvironment. Here, we performed an extensive clinical and bioinformatic analysis to explore the association between KDM5 mutation and tumor immunity and its impact on the outcomes in pan-cancer immunotherapy. In 2943 patients across 12 tumor types treated with immune checkpoint inhibitors, KDM5-mutant tumors were associated with favorable overall survival (hazard ratio, 0.

View Article and Find Full Text PDF

Advances in A-to-I RNA editing in cancer.

Mol Cancer

December 2024

NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.

RNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers. One of the most prevalent forms of RNA modifications in humans is adenosine-to-inosine (A-to-I) editing, catalyzed by the enzyme adenosine deaminase acting on RNA (ADAR) in double-stranded RNA (dsRNA).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!