Medicinal properties of for the control of type 2 diabetes mellitus: a systematic review.

The objective of this review was to evaluate the medicinal potential of leaves on the control of type 2 diabetes mellitus (DM2). The research question was: what is the therapeutic potential of leaves for the control of DM2? This systematic review was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. The included studies were extracted from Scopus, Pubmed, ScienceDirect, Scielo, and Google Scholar; January 2015 to July 2021. Key search terms were MeSH and DeCS: , mulberry, hypoglycemic agent. The inclusion criteria were: studies in rats administered leaf extracts; studies that included the dimensions of lipidemia and glycemia; studies that included indicators such as fasting glucose, postprandial glucose, glycosylated hemoglobin, triglycerides, low-density lipoproteins, total cholesterol, and insulin resistance. Exclusion criteria: studies in which leaves were administered with other plants; studies with other parts of the plant; proteomic studies, cancer, duplicate studies, studies, and evaluation of included studies. All included investigations were evaluated for biases. Of 253 studies found, 29 were included. The extracts of leaves at the phytochemical level improve glucose uptake. Chlorogenic acid, isoquercitrin, and quercitrin, present in the leaves of , have hypoglycemic properties and an ameliorating effect on diabetic nephropathy. This leaf has pharmacological effects such as glucose absorption, insulin secretion production, antioxidant and anti-inflammatory agent, antihyperglycemic and antihyperlipidemic activities, and obesity management. leaves have pharmacological effects on DM2 that include glucose absorption, production of insulin secretion, antioxidant agent, antihyperglycemic and antihyperlipidemic activities, and obesity control. Beyond these results, there is a lack of studies on the potential and synergistic effects of leaves' components, limiting the possibility of a more effective therapy using the plant's leaves.