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N-acetylmuramic acid recognition by MurK kinase from the MurNAc auxotrophic oral pathogen Tannerella forsythia.
J Biol Chem
September 2023
Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany. Electronic address:
The bacterial cell wall consists of a three-dimensional peptidoglycan layer, composed of peptides linked to the sugars N-acetylmuramic acid (MurNAc) and GlcNAc. Unlike other bacteria, the pathogenic Tannerella forsythia, a member of the red complex group of bacteria associated with the late stages of periodontitis, lacks biosynthetic pathways for MurNAc production and therefore obtains MurNAc from the environment. Sugar kinases play a crucial role in the MurNAc recycling process, activating the sugar molecules by phosphorylation.
View Article and Find Full Text PDFChronic N-acetylcysteine treatment improves anhedonia and cognition in a mouse model of the schizophrenia prodrome.
Front Behav Neurosci
September 2022
Institute of Applied Physiology, Ulm University, Ulm, Germany.
Schizophrenia is a severe psychiatric disorder whose neurodevelopmental pathogenesis includes a prodromal phase before its diagnostically decisive-namely psychotic-symptoms are present. This prodrome is characterized by cognitive and affective deficits, and it may constitute a critical time period for an early therapeutic intervention to improve or even prevent further disease development. N-acetylcysteine (NAC) is an easily repurposable compound that has recently shown promise in improving non-psychotic symptoms in patients with established schizophrenia.
View Article and Find Full Text PDFNovel Pyrrolo [3,4-b] Dithieno [3, 2-f:2″,3″-h] Quinoxaline-8,10 (9H)-Dione Based Wide Bandgap Conjugated Copolymers for Bulk Heterojunction Polymer Solar Cells.
Macromol Rapid Commun
May 2022
Department of Physics, The LNM Institute for Information Technology, Jamdoli, Jaipur, Rajasthan, 302031, India.
Two D-A copolymers consisting of fused ring pyrrolo-dithieno-quinoxaline acceptors are synthesized with different donor units, i.e., benzodithiophene (BDT) with alkylthienyl (P134) and 2-ethylhexyloxy (P117) side chains.
View Article and Find Full Text PDF36th International Symposium on Intensive Care and Emergency Medicine : Brussels, Belgium. 15-18 March 2016.
Crit Care
April 2016
Fondazione IRCCS Ca’ Granda - Ospedale maggiore Policlinico, Milan, Italy
Article Synopsis
- Sepsis negatively affects capillary function and oxygen delivery, potentially worsening patient outcomes.
- Lower levels of immunoglobulin G2 do not contribute to severe flu complications, suggesting other factors may play a role in flu severity.
- New research indicates that intravenous immunoglobulin may provide brain protection during sepsis by blocking harmful immune responses such as complement activation and apoptosis. *
25th Annual Computational Neuroscience Meeting: CNS-2016.
BMC Neurosci
August 2016
Institut de Neuroscienes de la Timone (INT), CNRS & Aix-Marseille University, 27 Boulevard Jean Moulin, 13005 Marseille, France
Article Synopsis
- The text includes a collection of research topics related to neural circuits, mental disorders, and computational models in neuroscience.
- It features various studies examining the functional advantages of neural heterogeneity, propagation waves in the visual cortex, and dendritic mechanisms crucial for precise neuronal functioning.
- The research covers a range of applications, from understanding complex brain rhythms to modeling auditory processing and investigating the effects of neural regulation on behavior.
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