Background: Our goal was to compare the metabolic curves of plasma clearance of iohexol (Cl) at standard dose (5 ml) and contrast-level dose (50 ml).
Methods: The concentration of iohexol was measured at fasting state and at nine different time periods after a single bolus of iohexol injection. The interval between the injection of the two doses was longer than 24 hrs. Using a multi-point method and a dual-sample method, Cl and Cl were calculated, and the correlation and consistency of Cl between the two doses were compared.
Results: The metabolic curves of iohexol at the 5 ml and 50 ml injection were substantially identical. The correlation of Cl between the two doses was 0.930, the mean deviation was 1.3 ± 6.9 ml/min/1.73 m. Taking Cl as the standard, the Cl at 2 h and 4 h had a correlation coefficient of 0.975, a mean deviation of 0.1 ± 5.3 ml/min/1.73 m, and the concordances were 100% corresponding to P, 88.9% corresponding to P, and 77.8% corresponding to P.
Conclusion: When a regular dose of iohexol is used for enhanced CT, Cl can be used for the measurement of GFR, and a proper time for blood collection can be 2 h and 4 h.
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