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Hemoglobin Himeji as a cause of interference in the measurement of glycated hemoglobin.
Endocrinol Diabetes Nutr (Engl Ed)
November 2021
Servicio de Endocrinología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.
Hemoglobin Himeji as a cause of interference in the measurement of glycated hemoglobin.
Endocrinol Diabetes Nutr (Engl Ed)
December 2020
Servicio de Endocrinología y Nutrición, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.
Hemoglobin Himeji and inconsistent hemoglobin A1c values: a case report.
J Med Case Rep
July 2017
Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar de São João E.P.E, Porto, Portugal.
Background: Hemoglobin A1c is used to evaluate the glycemic control in patients with diabetes and is a risk marker for chronic complications of diabetes. Hemoglobin variants are reported to falsely lower or increase hemoglobin A1c test results. We present a case report of a patient with diabetes with discrepancy between fasting plasma glucose and hemoglobin A1c due to the presence of hemoglobin Himeji, a clinically silent and very rare hemoglobinopathy.
View Article and Find Full Text PDFAldimine Formation Reaction, the First Step of the Maillard Early-phase Reaction, Might be Enhanced in Variant Hemoglobin, Hb Himeji.
Ann Clin Lab Sci
September 2016
Department of Internal Medicine, Kuma Hospital, Kobe, Japan.
Hb Himeji (β140Ala→Asp) is known as a variant hemoglobin in which glycation is enhanced and HbA1c measured by immunoassay shows a high value. The phenomenon of enhanced glycation in Hb Himeji is based on the fact that the glycation product of variant hemoglobin (HbX1c) shows a higher value than HbA1c. In this study, we investigated whether aldimine formation reaction, the first step of the Maillard early-phase reaction, is enhanced in Hb Himeji in vitro.
View Article and Find Full Text PDFMethod-dependent HbA1c values in a family with hemoglobin Himeji.
Clin Chim Acta
August 2011
Kuma Hospital, Japan.
Background: Hb Himeji is variant hemoglobin associated with increased glycation in a mutated β chain. We measured HbA1c using various methods in a family with Hb Himeji.
Methods: The proband was a 42-y female.
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