Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
We developed a novel nanostructure DNA probe for the detection of and miR-192 in retinoblastoma (RB) and to study the correlation between and miR-192 expression and RB development. and miR-192 nanostructure DNA probes were carried by silica particles and coated by dioleoyl-trimethy-lammonium-propane, which enhances their organizational compatibility and infiltration capacity. This probe has stable physicochemical properties and high specificity and sensitivity to detect and miR-192 both in RB cell lines and RB tissues. Using and miR-192 nanostructure DNA probes in RB tissue and cell lines, we found that the expression of drastically increased, but to the contrary, miR-192 was not expressed. After transfection, and miR-192 were overexpressed or silenced in RB116 cells, and we found that could effectively increase the activity and invasion of this RB cell line and reduce its apoptosis level, while miR-192 antagonized this tumor-promoting effect. Therefore, miR-192 can be used as an early biomarker of RB, and may be a new prognostic marker and therapeutic target for the treatment of RB.
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Source |
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http://dx.doi.org/10.1166/jbn.2021.3185 | DOI Listing |
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