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Nanofluorescence Probes to Detect miR-192/Integrin Alpha 1 and Their Correlations with Retinoblastoma. | LitMetric

We developed a novel nanostructure DNA probe for the detection of and miR-192 in retinoblastoma (RB) and to study the correlation between and miR-192 expression and RB development. and miR-192 nanostructure DNA probes were carried by silica particles and coated by dioleoyl-trimethy-lammonium-propane, which enhances their organizational compatibility and infiltration capacity. This probe has stable physicochemical properties and high specificity and sensitivity to detect and miR-192 both in RB cell lines and RB tissues. Using and miR-192 nanostructure DNA probes in RB tissue and cell lines, we found that the expression of drastically increased, but to the contrary, miR-192 was not expressed. After transfection, and miR-192 were overexpressed or silenced in RB116 cells, and we found that could effectively increase the activity and invasion of this RB cell line and reduce its apoptosis level, while miR-192 antagonized this tumor-promoting effect. Therefore, miR-192 can be used as an early biomarker of RB, and may be a new prognostic marker and therapeutic target for the treatment of RB.

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Source
http://dx.doi.org/10.1166/jbn.2021.3185DOI Listing

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