Polydopamine-assisted decoration of Se nanoparticles on curcumin-incorporated nanofiber matrices for localized synergistic tumor-wound therapy.

The management of surgical wounds incurred during tumor removal procedures has become a non-negligible issue. Herein, for the first time, an implantable polymer-based nanofiber matrix is developed for postoperative tumor management by promoting wound healing and preventing cancer recurrence. The multifunctional matrix is successfully prepared by assembling chitosan-stabilized Se nanoparticles (SeNPs) at the surface of polydopamine (PDA) modified poly(ε-caprolactone)/curcumin fibres (PCL/CUR), denoted as PCL/CUR/PDA@Se. In this system, PDA as functionalized layers coated onto the PCL/CUR surface favors the effective immobilization of SeNPs through a covalent bond, as well as acts as a gatekeeper guaranteeing the sustained release of CUR. The CUR/SeNPs present excellent antitumor efficacy, respectively, which supports the nanocomposite matrix to efficiently kill cancer cells by inducing mitochondrial dysfunction caused by the ROS overproduction, and significantly suppressing the tumor growth . Additionally, due to the synergistic antioxidant activity of CUR and SeNPs, the nanofibrous matrix distinctly facilitates the adhesion and proliferation of normal fibroblast cells, and simultaneously accelerates wound healing during tumor treatments in tumor-bearing mice. These results suggest that the PCL/CUR/PDA@Se matrix with bifunctional properties is a promising candidate for local tumor-wound therapy. This work offers an innovative strategy to develop new improved post-surgery therapies for cancer patients.