AI Article Synopsis
- A new bifunctional ligand with chiral NHC and prolinol groups is developed for use in catalysis.
- The ligand facilitates asymmetric allylic alkylation reactions with a Cu/Zn bimetallic complex, producing various γ-vinyl ketones selectively.
- Computational calculations indicate that the interactions between the ligand and substrates enhance the reaction’s selectivity and efficiency.
Article Abstract
A new bifunctional ligand bearing chiral N-heterocyclic carbene (NHC) and prolinol moieties is presented. Utilizing the designed ligand, an in situ formed Cu/Zn hetero-bimetallic complex unlocks the asymmetric allylic alkylation reactions of allyl phosphates with zinc keto-homoenolates, leading to the formation of various γ-vinyl ketones with good regio- and enantio-selectivity. DF sT calculation supports that the chelation of allyl phosphates with catalyst promotes the S 2' addition and the ligand-substrate steric interactions account for the stereoselective outcome.
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| http://dx.doi.org/10.1002/chem.202104268 | DOI Listing |
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