In the late 1930s, a team of physicists from the National Bureau of Standards (now the National Institute of Standards and Technology) published eight papers on the investigation of cosmic rays in the atmosphere. Payloads launched with weather balloons, also known as radiosondes, were equipped with sensors to measure temperature, relative humidity, pressure, and radiation dose. A battery-operated telemetry system was used to continuously transmit at 60 MHz to a base station. They measured the radiation dose profiles of cosmic radiation in the atmosphere up to 21 km. Calibration of the Geiger-Müller counters with a standard radium source allowed them to calculate a radiation dose rate at an altitude corresponding to 10 kPa that was 180 times the dose rate near sea level in Washington, DC. Ascents in Washington, DC (latitude 39 degrees) and Lima, Peru (near equator) allowed them to demonstrate the effects of Earth's magnetic field on incident galactic cosmic rays; the dose rate in Peru was only half that in Washington, DC.
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http://dx.doi.org/10.6028/jres.125.001 | DOI Listing |
Curr Oncol Rep
January 2025
Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, USA.
Purpose: To review recent advances with radiation therapy (RT) for soft tissue sarcomas (STS).
Recent Findings: Newer data showcases hypofractionated preoperative RT for soft tissue sarcomas treated with surgery to be safe and effective, however, long-term follow up data is pending. Hypofractionated and dose-escalated RT in patients with unresectable STS is also being studied, for which we remain optimistic given advances in RT planning approaches.
Radiology
January 2025
From the Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 (Y.Z., D.F.Y., C.I.H.); and Department of Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (Y.Z.).
Lung cancer is the leading cause of cancer deaths globally. In various trials, the ability of low-dose CT screening to diagnose early lung cancers leads to high cure rates. It is widely accepted that the potential benefits of low-dose CT screening for lung cancer outweigh the harms.
View Article and Find Full Text PDFIndian J Clin Biochem
January 2025
Department of Biochemistry, College of Medicine and J.N.M Hospital, WBUHS, Kalyani, West Bengal 741235 India.
Radiation therapy uses ionizing radiation (IR) to kill cancer cells. However, during radiotherapy normal cells are also damaged and killed by the generation of reactive oxygen species. Polyphenolic compounds are known to mitigate the damaging effects of radiation.
View Article and Find Full Text PDFCancer Biol Ther
December 2025
Department of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou, China.
Background And Purpose: Bone metastasis is common for breast cancer and associated with poor prognosis. Currently, radiotherapy (RT) serves as the standard treatment for patients exhibiting symptoms of bone metastasis to alleviate pain. Whether earlier application of RT will better control bone metastasis remains unclear.
View Article and Find Full Text PDFCancer Sci
January 2025
Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
To report clinical outcomes following highly hypofractionated biaxially rotational dynamic radiation therapy (BROAD-RT), a unique radiation therapy method that facilitates non-coplanar volumetric-modulated arc therapy (VMAT) without the need to rotate the couch or reposition the patient, for high-risk prostate cancer (PCa) with simultaneous integrated boost (SIB) for intra-prostatic dominant lesions (IPDLs), we performed a single-center prospective pilot study. In this study, patients with high-risk PCa according to the D'Amico classification or those with cT3aN0M0 PCa were eligible. VMAT was performed using BROAD-RT, and a dose of 54 Gy in 15 fractions was prescribed for the prostate in combination with SIB for IPDLs at a dose of 57 Gy in 15 fractions.
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