AI Article Synopsis
- - Biologics, made from biological sources like bacteria or mammalian cells, are increasingly used in pharmaceuticals, especially vaccines; plant molecular farming offers a cheaper and adaptable alternative for producing these medications.
- - The review discusses current challenges in vaccination, like the need for cold storage, and how combining plant molecular farming with advanced materials can help create stable vaccines that are easier to produce in low-resource settings.
- - It also introduces innovative vaccine delivery methods, such as microneedle patches and platforms for intranasal and oral administration, while outlining future opportunities for using plant molecular farming in developing next-generation vaccines and biologics.
Article Abstract
Biologics - medications derived from a biological source - are increasingly used as pharmaceuticals, for example, as vaccines. Biologics are usually produced in bacterial, mammalian or insect cells. Alternatively, plant molecular farming, that is, the manufacture of biologics in plant cells, transgenic plants and algae, offers a cheaper and easily adaptable strategy for the production of biologics, in particular, in low-resource settings. In this Review, we discuss current vaccination challenges, such as cold chain requirements, and highlight how plant molecular farming in combination with advanced materials can be applied to address these challenges. The production of plant viruses and virus-based nanotechnologies in plants enables low-cost and regional fabrication of thermostable vaccines. We also highlight key new vaccine delivery technologies, including microneedle patches and material platforms for intranasal and oral delivery. Finally, we provide an outlook of future possibilities for plant molecular farming of next-generation vaccines and biologics.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647509 | PMC |
| http://dx.doi.org/10.1038/s41578-021-00399-5 | DOI Listing |
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