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Recent Advances in Developmental Hematopoiesis: Diving Deeper With New Technologies. | LitMetric

AI Article Synopsis

  • Hematopoietic stem cells (HSCs) develop through interactions with their microenvironment, or niche, which are crucial for maintaining their self-renewal and differentiation capacities.
  • * The aorta-gonad-mesonephros (AGM) region is the key area for HSC emergence during vertebrate embryonic development.
  • * This review highlights recent advancements in technology that help identify the supportive niche's cellular makeup and molecular mechanisms in the AGM region.

Article Abstract

The journey of a hematopoietic stem cell (HSC) involves the passage through successive anatomical sites where HSCs are in direct contact with their surrounding microenvironment, also known as niche. These spatial and temporal cellular interactions throughout development are required for the acquisition of stem cell properties, and for maintaining the HSC pool through balancing self-renewal, quiescence and lineage commitment. Understanding the context and consequences of these interactions will be imperative for our understanding of HSC biology and will lead to the improvement of production of HSCs for clinical purposes. The aorta-gonad-mesonephros (AGM) region is in this light of particular interest since this is the cradle of HSC emergence during the embryonic development of all vertebrate species. In this review, we will focus on the developmental origin of HSCs and will discuss the novel technological approaches and recent progress made to identify the cellular composition of the HSC supportive niche and the underlying molecular events occurring in the AGM region.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8652083PMC
http://dx.doi.org/10.3389/fimmu.2021.790379DOI Listing

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