AI Article Synopsis
- - Aging and neurodegenerative diseases disrupt the extracellular microenvironment, which includes elements like mesenchyme and body fluids.
- - Caloric restriction (CR) is a lifestyle change that not only helps prevent metabolic disorders but also enhances brain health by improving cognitive functions and slowing down neurodegenerative disease progression.
- - The article discusses how CR can protect the brain by affecting metabolism, autophagy, oxidative stress, and neuroinflammation, and it offers insights for future approaches to addressing brain aging.
Article Abstract
Aging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to preventing metabolic disorders, CR has been shown to improve brain health owing to its enhancing effect on cognitive functions or retarding effect on the progression of neurodegenerative diseases. This article summarizes current findings regarding the neuroprotective effects of CR, which include the modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. This review may offer future perspectives for brain aging interventions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660583 | PMC |
| http://dx.doi.org/10.3389/fphys.2021.715443 | DOI Listing |
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