AI Article Synopsis
- The study focuses on understanding the occurrence of acute neutropenia—a drop in white blood cells—caused by antibiotics, which is a rare side effect of these commonly prescribed medications.
- Researchers reviewed case reports from 1968 to 2020, ultimately identifying 83 cases and noting details such as treatment duration and recovery times.
- Results showed that neutropenia typically developed after about 21 days of treatment with antibiotics like vancomycin and ceftaroline, with recovery taking around 6 days; furthermore, discontinuation of the antibiotic or substitution led to better outcomes, highlighting the need for monitoring blood counts during treatment.
Article Abstract
Aims: Acute neutropenia induced by antibiotics is a rare side effect of this frequently prescribed class of drugs. We aim to find similarities and differences between reported cases.
Methods: Through a database search (PubMed, 1968-2020), we identified published case reports and extracted, among other data, patient demographics, duration of treatment with the respective agent, and duration of recovery.
Results: Overall, 83 cases were included. Neutropenia developed after a median (min-max) of 21 (17.5-28.5) days of treatment and was resolved after a median (min-max) of 6 (3.0-8.75) days. Vancomycin and ceftaroline emerged as the two most commonly described antibiotics. In 51.8% of cases, the suspected antibiotic was discontinued; in 37.4% of cases, it was substituted by another agent. Only three case reports mentioned death as a result of neutropenia. The use of granulocyte colony-stimulating growth factors (CSFs) shortened the duration of neutropenia and improved outcome for patients' health.
Conclusion: Neutropenia induced by antibiotics remains a rare or rarely reported side effect. Long-term and high-dose treatment regimens expose a higher risk of development. Thus, regular full blood counts are advised during therapy.
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| http://dx.doi.org/10.1111/bcp.15170 | DOI Listing |
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