AI Article Synopsis
- Oxidative damage to DNA is linked to aging and disease progression, highlighting its significance in health research.
- Nucleoside-derived radicals are crucial in DNA oxidation, but current methods for analyzing them are limited.
- The study introduces a new technique using a profluorescent nitroxide probe combined with liquid chromatography-fluorometry and high-resolution tandem mass spectrometry for detecting and analyzing these radicals in damaged DNA.
Article Abstract
The oxidative damage of DNA is associated with aging and the development of various diseases. Although nucleoside-derived radicals play an important role in DNA oxidation, their analysis methods are limited. Herein, we propose a fluorometric detection and structural analysis of radicals on the surface of oxidatively damaged DNA using a profluorescent nitroxide probe combined with liquid chromatography-fluorometry and high-resolution tandem mass spectrometry.
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| http://dx.doi.org/10.1039/d1cc04998d | DOI Listing |
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