AI Article Synopsis
- Urinary incontinence (UI) is a common condition caused by weak urethral sphincter muscles, and new approaches like cell therapy aim to improve their function.
- Researchers are exploring innovative needle-free waterjet (WJ) technology to inject cells more effectively into the urethral sphincter during procedures.
- In a study, WJ was used to deliver porcine adipose tissue-derived stromal cells (pADSCs) into urethral tissue, showing reduced cellular elasticity and a cell viability rate above 80%, despite being lower than controls.
Article Abstract
Urinary incontinence (UI) is a highly prevalent condition characterized by the deficiency of the urethral sphincter muscle. Regenerative medicine branches, particularly cell therapy, are novel approaches to improve and restore the urethral sphincter function. Even though injection of active functional cells is routinely performed in clinical settings by needle and syringe, these approaches have significant disadvantages and limitations. In this context, needle-free waterjet (WJ) technology is a feasible and innovative method that can inject viable cells by visual guided cystoscopy in the urethral sphincter. In the present study, we used WJ to deliver porcine adipose tissue-derived stromal cells (pADSCs) into cadaveric urethral tissue and subsequently investigated the effect of WJ delivery on cell yield and viability. We also assessed the biomechanical features (i.e., elasticity) by atomic force microscopy (AFM) measurements. We showed that WJ delivered pADSCs were significantly reduced in their cellular elasticity. The viability was significantly lower compared to controls but is still above 80%.
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