AI Article Synopsis
- EMR (Endoscopic Mucosal Resection) is a common treatment for colorectal lesions, and some doctors add epinephrine to the injection used during the procedure.
- A study was conducted to see if adding epinephrine increases pain after the procedure by comparing two groups: one with epinephrine and one without.
- Results showed that patients who received epinephrine reported significantly higher pain levels at both 30 and 60 minutes post-procedure and had longer recovery times.
Article Abstract
Background And Aims: EMR is first-line therapy for colorectal laterally spreading lesions. Some colonoscopists include epinephrine in the submucosal injectate, which we observed increased postprocedure discomfort. Our aim was to determine whether inclusion of epinephrine in the submucosal injectate increases postprocedure pain after EMR.
Methods: We performed a randomized, controlled, double-blind trial comparing epinephrine in submucosal injectate versus injectate alone for abdominal pain at 30 and 60 minutes after EMR.
Results: Mean polyp diameter in both arms was >40 mm. There were no differences in procedure times or amounts of fluid injected. Mean pain was higher on a visual analog scale in the epinephrine group at 30 minutes (47 vs 14, P = .022) and at 60 minutes (44 vs 13, P = .035). Recovery room stay was longer in the epinephrine group (68 vs 53 minutes, P = .034).
Conclusions: Epinephrine in the submucosal injectate for EMR increases postprocedural pain, which could cause diagnostic confusion and prolong observation time in the recovery area. (Clinical trial registration number: NCT04065451.).
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Source |
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| http://dx.doi.org/10.1016/j.gie.2021.11.043 | DOI Listing |
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