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Discovery of Novel Spirocyclic MAT2A Inhibitors Demonstrating High In Vivo Efficacy in MTAP-Null Xenograft Models.
J Med Chem
January 2025
Medicinal Chemistry Department, Shanghai Haiyan Pharmaceutical Technology Co., Ltd., Pudong New Area, Shanghai 201203, China.
Synthetic lethality offers a robust strategy for discovering the next generation of precision medicine therapies tailored for molecularly defined patient populations. MAT2A inhibition is synthetically lethal in several cancers that exhibit a homozygous deletion of -methyl-5'-thioadenosine phosphorylase (MTAP). Herein, we report the identification of novel MAT2A inhibitors featuring a spiral ring to circumvent the C-N atropisomeric chirality utilizing structure-based drug design.
View Article and Find Full Text PDFAssociation between exposure to environmental pollutants and increased oral health risks, a comprehensive review.
Front Public Health
January 2025
Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
The burden of disease and death attributable to environmental pollution is a growing public health challenge worldwide, particularly in developing countries. While the adverse effects of environmental pollution on oral health have garnered increasing attention, a comprehensive and systematic assessment remains lacking. This article delves into the intricate relationship between environmental pollution and oral health, highlighting significant impacts on various aspects such as dental caries, periodontal diseases, oral facial clefts, cancer, as well as other oral diseases.
View Article and Find Full Text PDFUnmasking Lead Exposure and Neurotoxicity: Epigenetics, Extracellular Vesicles, and the Gut-Brain Connection.
Indian J Clin Biochem
January 2025
Jaipur, India.
Assessment of the Knowledge of Healthcare Professionals Regarding Radiological Examination in Lactating Mothers: A Cross-Sectional Survey Study in the Kingdom of Bahrain.
Cureus
December 2024
Pediatrics and Neonatology, Bahrain Defence Force Royal Medical Services, Riffa, BHR.
Objectives Breastfeeding is critical for a mother's health, as well as the development and survival of her infant. Healthcare personnel are a reliable source of information for breastfeeding mothers during and after radiological procedures, assuming their understanding is appropriate. As a result, this study analyzed healthcare professionals' knowledge of breastfeeding and radiological tests on lactating mothers.
View Article and Find Full Text PDFCoccidioidal Meningitis in a Patient With HIV.
Cureus
December 2024
Family Medicine Alexandria, Louisiana State University Health Sciences Center, Alexandria, USA.
Coccidioidal meningitis is a rare yet life-threatening complication of disseminated infection, primarily affecting immunocompromised individuals. and are dimorphic fungi endemic to the southwestern United States, where exposure to inhaled spores can lead to a range of clinical manifestations, including pulmonary and central nervous system (CNS) involvement. This report describes the case of a 27-year-old correctional officer with advanced human immunodeficiency virus (HIV) infection who presented with chronic headaches, altered mental status, and significant weight loss following his relocation from Arizona to Louisiana.
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