We report here on improved uniformity of blends of micronised active pharmaceutical ingredients (APIs) using addition of spherical agglomerates of lactose and enhanced blend flow to improve tablet content uniformity with higher API loads. Micromeritic properties and intra-particle porosity (using nano-computed X-ray tomography) of recently introduced spherical agglomerates of lactose and two standard lactose grades for the direct compression processes were compared. Powder blends of the individual lactose types and different micronised API drug loads were prepared and subjected to specific conditions that can induce API segregation. Tablet content uniformity during direct compression was related to the lactose material attributes. The distinctive micromeritic properties of the lactose types showed that spherical agglomerates of lactose had high intra-particle porosity and increased specific surface area. The stability of binary blends after intense sieving was governed by the intra-particle porosity and surface roughness of the lactose particles, which determined the retention of the model substance. Greater intra-particle porosity, powder specific surface area, and particle size of the spherical agglomerates provided greater adhesion of micronised particles, compared to granulated and spray-dried lactose. Thus the spherical agglomerates provided enhanced final blend flow and uniformity of tablet content at higher drug loads.
This study investigates the effectiveness of polyaniline oxide (PANI) nanoparticles as photocatalysts for the degradation of organic dyes under visible light irradiation. Known for their stability and adjustable conductivity, PANI nanoparticles were synthesized a hydrothermal method using P123 surfactants, followed by calcination. The morphology, structural phase, and optical properties of the synthesized PANI materials were analyzed using scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS), Raman spectroscopy, and Fourier transform infrared spectroscopy (FTIR).
Carbon quantum dots (CQDs) derived from Walnut Shell biomass have been studied as effective fluorescent sensors for detecting Acebrophylline (AB), a medication for respiratory diseases.
The CQDs exhibit high selectivity and sensitivity towards AB, with a detection limit of 0.142 nM and strong performance in human urine samples, achieving recovery rates between 81 to 123%.
The study also analyzed structural changes in CQDs after sensing AB and explored the effects of various factors on detection, emphasizing the method's eco-friendly and cost-effective potential for healthcare applications.
The current study describes the biological synthesis of manganese oxide nanoparticles from Bacillus thuringiensis, as well as their characterization, biological activity, and toxicity. Nanoparticles may be synthesized in multiple ways, but the biogenic process is the most environmentally friendly and cost-effective. The optical, structural, and crystalline properties of the nanoparticles were investigated.
Acibadem Mehmet Ali Aydınlar University, Institute of Health Sciences, Department of Medical Biotechnology, Istanbul, Turkey; Acibadem Mehmet Ali Aydınlar University, School of Medicine, Department of Medical Microbiology, Istanbul, Turkey. Electronic address:
Background/purpose: Nanobacteria, known to date as self-replicating, nano-scale size organisms, smaller than bacteria. However, whether these are living organisms or agglomeration of biomolecules was one of the most controversial issues for many years. One of the reasons for debate is their lack of any genetic material.
Background: Liver in the body plays vital role including digestion, detoxification, metabolism and even production of hormones. Hepatocellular carcinoma is recognized as one of leading cause of death worldwide. Infection with hepatitis B and C virus, nonalcoholic fatty liver disease and excessive consumption of alcohol are among the most common risk factors associated with the development of hepatocellular carcinoma.
