There are more than 150 types of chemical modifications in RNA, mainly methylation, which are widely distributed in all kinds of RNA, including messenger RNA, transfer RNA, ribosomal RNA, non-coding small RNA and long non-coding RNA. In recent years, the identification of RNA methylation modification enzymes and the development of high-throughput sequencing technology at transcriptome level laid a foundation for revealing the expression and function of genes regulated by chemical modification of RNA. In this review, the most recent advances of RNA methylation, especially N6-methyladenosine (ma) in the blood system, including the regulation of RNA methyltransferases, RNA demethylases and RNA binding proteins on normal and malignant hematopoiesis through the regulation of RNA methylation level were summarized briefly.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.06.049 | DOI Listing |
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