AI Article Synopsis
- - The study analyzed clinical characteristics and prognosis factors in 205 children with severe aplastic anemia (SAA) treated from 2008 to 2018, focusing on their response to immunosuppressive therapy (IST).
- - Results showed that by 12 months post-treatment, over 73% of patients had a positive response, and the 5-year overall survival rate was impressive at 93.1%.
- - While the mode of delivery (spontaneous vs. cesarean) seemed to have an impact on short-term survival rates, it was not significant in the long term, and a recent history of home or school decoration was linked to better short-term responses to treatment.
Article Abstract
Objective: To analyze the clinical characteristics and factors affecting prognosis in children with severe aplastic anemia (SAA).
Methods: Two hundred and five children with SAA treated in our department from January 2008 to April 2018 were selected, and the clinical characteristics and factors affecting prognosis were retrospectively analyzed.
Results: Among 205 SAA children, the effective rate (CR+PR) at 3, 6 and 12 months after immunosuppressive therapy (IST) treatment was 50.9%, 59.0% and 73.9%, respectively, and 5-year overall survival rate was 93.1%±2.0%. Univariate analysis showed that 5-year overall survival rate of SAA children of spontaneous delivery was higher than that of cesarean section (P=0.039), while multivariate analysis showed that birth way had no significant influence on 5-year overall survival rate (P>0.05). The response rate at 3 months after IST of children with a recent history of decoration before SAA onset was higher than those without history of decoration (P<0.05).
Conclusion: Most of the SAA children can achieve high response rate and overall survival rate. Patients with recent history of home/school decoration may be the factor affecting hematological response after 3 months of IST, but have no influence on long-term overall survival.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.06.035 | DOI Listing |
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