Adaptive deep brain stimulation (aDBS) promises a significant improvement in patient outcomes, compared to existing deep brain stimulation devices. Fully implanted systems represent the next step to the clinical adoption of aDBS. We take advantage of a unique longitudinal data set formed as part of an effort to investigate aDBS for essential tremor to verify the long term reliability of electrocorticography strips over the motor cortex as a source of bio-markers for control of adaptive stimulation. We show that beta band event related de-synchronization, a promising bio-marker for movement, is robust even when used to trigger aDBS. Over the course of several months we show a minor increase in beta band event related de-synchronization in patients with active deep brain stimulation confirming that it could be used in chronically implanted systems.Clinical relevance - We show the promise and practicality of cortical electrocorticography strips for use in fully implanted, clinically translatable, aDBS systems.
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| http://dx.doi.org/10.1109/EMBC46164.2021.9629927 | DOI Listing |
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