Effect of Shock Vector Orientation in Modulating and Terminating Rotors - a Simulation Study.

The main treatment option for Ventricular Fibrillation (VF), especially in out-of-hospital cardiac arrests (OHCA) is defibrillation. Typically, the survival-to-discharge rates are very poor for OHCA. Existing studies have shown that rotors may be the sources of arrhythmia and ablating them could modulate or terminate VF. However, tracking rotors and ablating them is not a feasible solution in a OHCA scenario. Hence, if the sources (or rotors) can be regionally localized non-invasively and this information can be used to direct the orientation of the shock vectors, it may aid the termination of rotors and defibrillation success. In this work, using computational modeling, we present our initial results on testing the effect of shock vector orientation on modulating (or) terminating rotors. A combination of Sovilj's and Aliev Panfilov's monodomain cardiac models were used in inducing rotors and testing the effect of shock vector magnitude and direction. Based on our simulation results on an average with four experimental trials, a shock vector directed in the perpendicular direction along the axis of the rotor terminated the rotor with 16% lesser magnitude than parallel direction and 38% lesser magnitude than in oblique direction.Clinical Relevance- A rotor localization dependent defibrillation strategy may aid the defibrillation protocol procedures to improve the survival rates. Based on the four experimental trials, the results indicate shock vectors oriented perpendicular to the axis of the rotors were efficient in modulating or terminating rotors with lower magnitude than other directions.