Radiomic combination of spatial and temporal features extracted from DCE-MRI for prostate cancer detection.

Multi-parametric MRI is part of the standard prostate cancer (PCa) diagnostic protocol. Recent imaging guidelines (PI-RADS v2) downgraded the value of Dynamic Contrast-Enhanced (DCE)-MRI in the diagnosis of PCa. A purely qualitative analysis of the DCE-MRI time series, as it is generally done by radiologists, might indeed overlook information on the microvascular architecture and function. In this study, we investigate the discriminative power of quantitative imaging features derived from texture and pharmacokinetic analysis of DCE-MRI. In 605 regions of interest (benign and malignant tissue) delineated in 80 patients, we found through independent cross-validation that a subset of quantitative spatial and temporal features extracted from DCE-MRI and incorporated in machine learning classifiers obtains a good diagnostic performance (AUC = 0.80-0.86) in distinguishing malignant from benign regions.Clinical Relevance- These findings highlight the underlying potential of quantitative DCE-derived radiomic features in identifying PCa by MRI.