AI Article Synopsis
- Combining microfluidics and sensors creates advanced analysis systems, allowing for electrical sensing and analysis within tiny fluid channels.
- The paper outlines the challenges in connecting these microfluidic networks with electrical components and presents a new device for studying red blood cell flow.
- Results include the device's ability to distinguish red blood cells affected by sickle cell disease, highlighting its potential for clinical applications.
Article Abstract
Combining microfluidic with sensors enables the development of smart analysis systems. Microelectrodes can be embedded within the microchannels network for electrical sensing, electrochemical analysis or impedance measurement. However, at the laboratory scale, the assembly between microfluidic network and electrical parts on the substrate remains an issue. This paper first discusses the principles of biosensing, and then proposes an original device integrating microfluidics with microelectrodes for the analysis of red blood cells transit in a structure mimicking micro-vascular flow. Some results concerning red blood cells discrimination of sickle cell disease are discussed with statistical analysis.Clinical relevance- This paper introduces a portable reusable device combining a microfluidic blood vessel mimicking network with microelectrodes for the biosensing of RBC.
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| http://dx.doi.org/10.1109/EMBC46164.2021.9630178 | DOI Listing |
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