The synthesis of efficient porphyrin-based photosensitizers with intense near-infrared (NIR) absorption is in high demand for photodynamic therapy (PDT) but remains a challenging task. Herein we show the construction of a type of isoquinoline-fused porphyrins and with an impressive NIR-absorbing capacity. In light of the extraordinary singlet oxygen generation capabilities of upon NIR irradiation, the representative nanoparticles () assembled show excellent tumoricidal behavior with good biocompatibility in the phototherapeutic window (650-850 nm).
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Direct [4 + 2] Cycloaddition to Isoquinoline-Fused Porphyrins for Near-Infrared Photodynamic Anticancer Agents.
Org Lett
January 2022
Key Laboratory of Green Chemistry and Technology of the Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China.
The synthesis of efficient porphyrin-based photosensitizers with intense near-infrared (NIR) absorption is in high demand for photodynamic therapy (PDT) but remains a challenging task. Herein we show the construction of a type of isoquinoline-fused porphyrins and with an impressive NIR-absorbing capacity. In light of the extraordinary singlet oxygen generation capabilities of upon NIR irradiation, the representative nanoparticles () assembled show excellent tumoricidal behavior with good biocompatibility in the phototherapeutic window (650-850 nm).
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