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Localization is the key to action: regulatory peculiarities of lncRNAs.
Front Genet
December 2024
Department of Biophysics, Laboratory of DNA Repair and Aging, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
To understand the transcriptomic profile of an individual cell in a multicellular organism, we must comprehend its surrounding environment and the cellular space where distinct molecular stimuli responses are located. Contradicting the initial perception that RNAs were nonfunctional and that only a few could act in chromatin remodeling, over the last few decades, research has revealed that they are multifaceted, versatile regulators of most cellular processes. Among the various RNAs, long non-coding RNAs (LncRNAs) regulate multiple biological processes and can even impact cell fate.
View Article and Find Full Text PDFMedical students' perceptions of improving physician satisfaction and patient care: a text network analysis approach.
BMC Med Educ
December 2024
Center for Chung-Ang Medical Education Resource Allocation (CAMERA), College of Medicine, Chung-Ang University, Dongjak-gu, Seoul, Republic of Korea.
Background: Physicians' job satisfaction and their relationships with patients are critical factors in modern healthcare. Understanding medical students' perceptions of these aspects is crucial for enhancing the quality of healthcare. Hence, this study examined medical students' perspectives on improving physician job satisfaction and the essential patient-oriented attitudes required for developing into skilled physicians.
View Article and Find Full Text PDFEngaging rural communities in Bangladesh to tackle antimicrobial resistance through the Community Dialogue Approach: a process evaluation protocol for COSTAR project in Cumilla, Bangladesh.
Front Public Health
December 2024
Nuffield Centre for International Health and Development, Leeds Institute for Health Sciences, University of Leeds, Leeds, United Kingdom.
Introduction: Antimicrobial resistance (AMR) is a global problem and is especially threatening for low-and-middle income countries like Bangladesh. The COSTAR (Community-led Solutions to Antimicrobial Resistance) project includes a Randomised Control Trial (RCT) which aims to evaluate the effectiveness of the Community Dialog Approach (CDA) to improve levels of correct and appropriate knowledge and reported practice about antibiotics, antibiotic use, and antibiotic resistance (ABR) from a One Health perspective, among adult community members in 5 selected sub-districts of Cumilla. The CDA is a community engagement approach involving community members in active discussions also known as Community Dialogs (CD), run by local facilitators.
View Article and Find Full Text PDFSubseasonal Prediction of Heat-Related Mortality in Switzerland.
Geohealth
January 2025
Institute for Atmospheric and Climate Science, ETH Zurich Zurich Switzerland.
Heatwaves pose a range of severe impacts on human health, including an increase in premature mortality. The summers of 2018 and 2022 are two examples with record-breaking temperatures leading to thousands of heat-related excess deaths in Europe. Some of the extreme temperatures experienced during these summers were predictable several weeks in advance by subseasonal forecasts.
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