AI Article Synopsis
- * The incidence rate was significantly lower in the Amerindian population (0.09/100,000) compared to the general Chilean population (1.17/100,000), with a median patient age of 73 years at diagnosis.
- * Overall survival (OS) at five years was 56%, with poorer outcomes observed in men, patients aged 65 and older, and those classified as high-risk, indicating lower incidence and worse
Article Abstract
The study aim was to analyze incidence and presentation features of chronic lymphocytic leukemia (CLL) in Chile, in Amerindian population and in non-Native. Between 2012 and 2019, 912 patients were diagnosed, and 13 (1.4%) were Amerindian. The estimated incidence in Chilean population was 1.17/100,000 person per year, while in Amerindian, 0.09/100,000 person per year. Median age was 73 years. At diagnosis, 48, 27, and 25%, had low (0), intermediate (I/II) and high-risk (III/IV) disease on Rai classification. Diagnostic immunophenotypic Matutes score was ≥4 in 90%. Median follow-up was 37 months (range 2-87). 5-year OS was 56%, with median overall survival (OS) not reached. It was worse in men, ≥65 years, high-risk and those with increased prolymphocytes (CLL/PL). This study shows low incidence and worse OS in Chilean CLL patients, compared to those from European countries, despite similar clinical features. It also demonstrates that CLL is very uncommon in Amerindian population.
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| http://dx.doi.org/10.1080/10428194.2021.2012663 | DOI Listing |
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