The progressive collapse of buildings induces a variety of catastrophic consequences, such as casualties and property loss over the past few decades. The corner column is more prone to abnormal load events compared to the inner column and outer column; thus, it is easier to trigger progressive collapse. By considering the effects of floor slabs and adjacent bays on progressive collapse behavior, the pseudo-static loading method was used to study the progressive collapse test of a 1/3 scaled, one story, 2 × 2-bay cast-in-place reinforced concrete frame substructure under the removal condition of a corner column. The test results show that the flexural deformation principally concentrates upon the components of a directly affected part (DAP), and compressive arch actions are observed in members of the indirectly affected part (IAP). Moreover, the slab adjacent to the removed column and periphery elements contributes great resistance to a progressive collapse.
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http://dx.doi.org/10.3390/ma14237157 | DOI Listing |
Spine J
January 2025
Department of Thoracic Surgery, Kyoto University, Graduate School of Medicine.
Background Context: Scoliosis is a potential postoperative complication of various pediatric cardiothoracic conditions.
Purpose: To investigate the incidence of scoliosis in pediatric lung transplant patients and explore the factors associated with its development.
Study Design: Retrospective observational study PATIENT SAMPLE: 330 consecutive lung transplant recipients at a single institution between April 2002 and June 2022.
J Clin Med
January 2025
Department of Cardiovascular & Thoracic Anaesthesia and Critical Care, University Hospital of Martinique, F-97200 Fort-de-France, Martinique, France.
Acute cardiovascular disorders are incriminated in up to 33% of maternal deaths, and the presence of sickle cell anemia (SCA) aggravates the risk of peripartum complications. Herein, we present a 24-year-old Caribbean woman with known SCA who developed a vaso-occlusive crisis at 36 weeks of gestation that required emergency Cesarean section. In the early postpartum period, she experienced fever with rapid onset of acute respiratory distress in the context of COVID-19 infection that required tracheal intubation and mechanical ventilatory support with broad-spectrum antibiotics and blood exchange transfusion.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, China.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and devastating lung disorder. In response to transforming growth factor-β (TGF-β), normal lung cells proliferate and differentiate into myofibroblasts, which are instrumental in promoting disease progression. Small interfering RNA (siRNA) targeting heat shock protein 47 (HSP47) has been demonstrated to alleviate IPF by blocking collagen synthesis and secretion.
View Article and Find Full Text PDFEur J Med Res
January 2025
Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, NO. 3 Qingchun East Road, Hangzhou, 310016, China.
Background: Ovarian cancer (OC) is a prevalent gynecological malignancy with a relatively dismal prognosis. The SGT1 homolog (SUGT1) protein, which interacts with heat shock protein 90 and is essential for the G1/S and G2/M transitions, was formerly thought to be a cancer promoter, but its precise role in OC remains unknown.
Methods: We conducted a comprehensive bioinformatics analysis of SUGT1 expression in patients with OC compared with their normal controls, including the data from the cancer genome atlas (TCGA), genotype-tissue expression (GTEx) databases, gene ontology (GO) analysis, Kyoto Encylopedia of Genes and Genomes (KEGG) analysis, gene set enrichment analysis (GSEA), single sample gene set enrichment analysis (ssGSEA).
Signal Transduct Target Ther
January 2025
Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China.
Mitochondria are essential for cellular function and viability, serving as central hubs of metabolism and signaling. They possess various metabolic and quality control mechanisms crucial for maintaining normal cellular activities. Mitochondrial genetic disorders can arise from a wide range of mutations in either mitochondrial or nuclear DNA, which encode mitochondrial proteins or other contents.
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