AI Article Synopsis
- Cytokine storm is an excessive immune response where high levels of cytokines are released, often triggered by acute infections, affecting multiple cell types and varying across different diseases.
- This review discusses the biological mechanisms that lead to cytokine storms in infectious diseases and explores treatment strategies aimed at managing these responses from both the host’s and the pathogen’s viewpoints.
- Research suggests that targeted therapies can reduce tissue damage and help clear infections, with advancements in "multi-omics" profiling expected to improve treatment strategies for cytokine storms across various diseases.*
Article Abstract
Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, "multi-omics" immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8658039 | PMC |
| http://dx.doi.org/10.3390/ijms222313009 | DOI Listing |
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