Molecular Pathogenesis of the Coronin Family: Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma.

In humans, the coronin family is composed of seven proteins containing WD-repeat domains that regulate actin-based cellular processes. Some members of the coronin family are closely associated with cancer cell migration and invasion. The Cancer Genome Atlas (TCGA) analysis revealed that , , and were significantly upregulated in oral squamous cell carcinoma (OSCC) tissues ( < 0.05). Moreover, the high expression of was significantly predictive of the 5-year survival rate of patients with OSCC ( = 0.0203). Overexpression of was detected in OSCC clinical specimens by immunostaining. siRNA-mediated knockdown of suppressed cancer cell migration and invasion abilities. Furthermore, we investigated the involvement of microRNAs (miRNAs) in the molecular mechanism underlying overexpression in OSCC cells. TCGA analysis confirmed that tumor-suppressive and were significantly downregulated in OSCC tissues. Notably, these miRNAs bound directly to the 3'-UTR of and controlled expression in OSCC cells. In summary, we found that aberrant expression of facilitates the malignant transformation of OSCC cells, and that downregulation of tumor-suppressive miRNAs is involved in overexpression. Elucidation of the interaction between genes and miRNAs will help reveal the molecular pathogenesis of OSCC.