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Spatially Resolved Single-Cell Transcriptome Analysis of Mycosis Fungoides Reveals Distinct Biomarkers GNLY and FYB1 Compared With Psoriasis and Chronic Spongiotic Dermatitis.
Mod Pathol
December 2024
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:
Article Synopsis
- Early mycosis fungoides (MF) can be challenging to distinguish from psoriasis and chronic spongiotic dermatitis, prompting research into diagnostic markers.
- The study involved analyzing T cells in skin samples using single-cell transcriptomics, finding 41 differentially expressed genes (DEGs) linked to T-cell receptor (TCR) signaling and apoptosis regulation specifically in MF.
- GNLY and FYB1 emerged as potential diagnostic biomarkers, showing promising sensitivity and specificity in differentiating MF from the other conditions, with GNLY having an AUC of 0.86 and FYB1 0.79.
Background And Objectives: Small fiber neuropathy (SFN) is characterized by dysfunction and loss of peripheral unmyelinated and thinly myelinated nerve fibers, resulting in a phenotype that includes varying combinations of somatosensory and dysautonomia symptoms, which can be profoundly disabling and lead to decreased quality of life. Treatment aimed mainly at pain reduction, which may not target the underlying pathophysiology, is frequently ineffective. Another impediment to the effective management of SFN may be the significant between-patient heterogeneity.
View Article and Find Full Text PDFFor herpes zoster (HZ) infection, early diagnosis and treatment are important in order to shorten the course of the disease and reduce sequelae, however, there is a lack of non-invasive diagnostic methods. Reflectance confocal microscopy (RCM) is a non-invasive technique often used to diagnose dyspigmented dermatosis, skin tumours, human papillomavirus infectious dermatosis, etc. To evaluate the clinical value of RCM for the early diagnosis of HZ.
View Article and Find Full Text PDFBackground: Actinic keratoses (AK) are pre-malignant skin lesions caused by chronic sun exposure. Progression from an AK to intraepidermal carcinoma (IEC) and a cutaneous squamous cell carcinoma (SCC) is well known but the rate of transformation to an invasive SCC is highly variable. Since no definitive biomarkers are available, treatment decisions are made ad hoc.
View Article and Find Full Text PDFPenile melanoma diagnosis aided by in vivo confocal microscopy.
JAAD Case Rep
February 2024
University Hospital Galway, National University of Ireland Galway.
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