A recent publication in Nature (Kaptein et al., 2021) reports a highly potent antiviral compound against dengue with promising efficacy in mice. Here, we track the history of this compound class, its pharmacology, and its chemistry, with insights into its potential as orally available drugs to prevent and treat dengue.
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| http://dx.doi.org/10.1016/j.chom.2021.11.010 | DOI Listing |
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Laser-based imaging approach for nocturnal vessel detection in rivers.
Sci Rep
December 2024
Computing for Sustainability and Social Good (C2SG) Research Group, United International University, Dhaka, Bangladesh.
In the twenty-first century, maritime routes are crucial for geographical and financial reasons in riverine countries. Compared to the available technology abroad, Bangladesh has insufficient monitoring of water vessels to tackle any possible disaster, such as vessel collisions for inland water transportation. One of the frequent outcomes of this architecture is regular capsizing, which sometimes leads to loss of lives.
View Article and Find Full Text PDFIntelligent vehicle trajectory tracking with an adaptive robust nonsingular fast terminal sliding mode control in complex scenarios.
Sci Rep
December 2024
School of Vehicle and Energy, Yanshan University, 438 West Hebei Avenue, Qinhuangdao, 066004, People's Republic of China.
This study presents a strategy for an intelligent vehicle trajectory tracking system that employs an adaptive robust non-singular fast terminal sliding mode control (ARNFTSMC) approach to address the challenges of uncertain nonlinear dynamics. Initially, a path tracking error system based on mapping error is established, along with a speed tracking error system. Subsequently, a novel ARNFTSMC strategy is introduced to tackle the uncertainties and external perturbations encountered during actual vehicle operation.
View Article and Find Full Text PDFWildlife trade investigations benefit from multivariate stable isotope analyses.
Biol Rev Camb Philos Soc
December 2024
School of Biological Sciences, Kadoorie Biological Sciences Building, The University of Hong Kong, Pok Fu Lam Road, Hong Kong, SAR, China.
The investigation of wildlife trade and crime has benefitted from advances in technology and scientific development in a variety of fields. Stable isotope analysis (SIA) represents one rapidly developing approach that has considerable potential to contribute to wildlife trade investigation, especially in complementing other methods including morphological, genetic, and elemental approaches. Here, we review recent progress in the application of SIA in wildlife trade research to highlight strengths, shortcomings, and areas for development in the future.
View Article and Find Full Text PDFRobust assessment of the cortical encoding of word-level expectations using the temporal response function.
J Neural Eng
December 2024
Trinity College Dublin, College Green, Dublin 2, Dublin, D02 PN40, IRELAND.
Speech comprehension involves detecting words and interpreting their meaning according to the preceding semantic context. This process is thought to be underpinned by a predictive neural system that uses that context to anticipate upcoming words. Recent work demonstrated that such a predictive process can be probed from neural signals recorded during ecologically-valid speech listening tasks by using linear lagged models, such as the temporal response function.
View Article and Find Full Text PDFThe effect of workload on mind-wandering of drilling operators measured by electroencephalography (EEG).
Exp Brain Res
December 2024
Department of Rehabilitation Medicine, Xindu District People's Hospital, Chengdu, 610500, China.
Mind wandering can cause workers to overlook safety hazards and delay making accurate operational decisions, ultimately raising the potential for accidents. However, there is relatively little research on the physiological characteristics of drilling workers during mind wandering. The aim of this investigation was to tackle the constraints of previous studies and to establish a more comprehensive theoretical framework and practical guidance for safety management.
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