Objective: This paper presentsa safe and effective keyhole neurosurgery intra-operative planning framework for flexible neurosurgical robots. The framework is intended to support neurosurgeons during the intra-operative procedure to react to a dynamic environment.
Methods: The proposed system integrates inverse reinforcement learning path planning algorithm combined with 1) a pre-operative path planning framework for fast and intuitive user interaction, 2) a realistic, time-bounded simulator based on Position-based Dynamics (PBD) simulation that mocks brain deformations due to catheter insertion and 3) a simulated robotic system.
Results: Simulation results performed on a human brain dataset show that the inverse reinforcement learning intra-operative planning method can guide a steerable needle with bounded curvature to a predefined target pose with an average targeting error of 1.34 ± 0.52 (25 = 1.02, 75 = 1.36) mm in position and 3.16 ± 1.06 (25 = 2, 75 = 4.94) degrees in orientation under a deformable simulated environment, with a re-planning time of 0.02 sec and a success rate of 100%.
Conclusion: With this work, we demonstrate that the presented intra-operative steerable needle path planner is able to avoid anatomical obstacles while optimising surgical criteria.
Significance: The results demonstrate that the proposed method is fast and can securely steer flexible needles with high accuracy and robustness.
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http://dx.doi.org/10.1109/TBME.2021.3133075 | DOI Listing |
Int J Surg
January 2025
Department of Surgery, American University of Beirut, Beirut, Lebanon.
Background: The reliability of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) in patients with initially node-positive breast cancer is still controversial. This meta-analysis is conducted to investigate the feasibility and accuracy of SLNB after NACT in patients with initially positive axillary nodes.
Methods: We conducted a literature search using Medline, PubMed, Embase, Central, and SCOPUS up until April 2021 for studies on the performance of SLNB following NACT.
Mol Neurobiol
January 2025
College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, 100039, China.
Circulating lipids and changes in lipid profiles have long been associated with the development of stroke but causal relationships remain unclear.In this study, we aimed to assess the causal relationships between lipid species and multiple stroke phenotypes to inform stroke prevention and treatment strategies. We conducted a two-sample Mendelian randomization analysis using data from genome-wide association studies.
View Article and Find Full Text PDFInt J Rheum Dis
January 2025
Department of Orthopedics, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei, China.
Objective: Osteoarthritis is a common joint disease caused by a variety of risk factors, and it has been found that many biochemical markers are abnormal in peripheral blood and urine of patients with OA. The aim of this study was to elucidate the causal relationship between biomarkers associated with these processes and OA using Mendelian randomization (MR) analysis.
Method: The inverse variance weighted (IVW) approach to MR was primarily used to explore causal associations between exposures and outcomes using publicly available genetic variants from large genome-wide association studies (GWAS).
Background: As the prevalence of osteoporotic fractures increases, impacting the health of the aging population significantly, understanding the genetic link between chronic diseases such as primary biliary cholangitis (PBC) and osteoporosis (OP) is crucial. Despite existing research, the direct genetic relationship between these conditions remains unclear.
Materials And Methods: This study used a two-sample Mendelian randomization approach, drawing on the largest available genome-wide association studies.
Nutr Metab Cardiovasc Dis
November 2024
Laboratory of Cell Signaling, Obesity and Comorbidities Research Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; Turku PET Centre, University of Turku, Turku, Finland. Electronic address:
Background And Aims: This study compares three methods to determine central adiposity (waist circumference -WC - and visceral adipose tissue - VAT - estimated by dual-energy x-ray absorptiometry - DXA, and by magnetic resonance imaging - MRI) in their ability to predict increases in cardiometabolic risk (CMR) markers in young individuals. We examined their associations with CMR in 47 men and women aged 25-40.
Methods And Results: VAT mass was assessed using DXA and MRI.
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