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Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma.
Cancer Biol Med
March 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).
View Article and Find Full Text PDFExploring the Role of Asymmetric Auditory and Tactile Stimulation on Modulating Gait Kinetics.
Annu Int Conf IEEE Eng Med Biol Soc
July 2024
This study explores the influence of Auditory Rhythmic Asymmetric Cueing (A-RAC), Tactile Rhythmic Asymmetric Cueing (T-RAC), and their combination (AT) on key kinetic gait parameters in gait rehabilitation: Vertical Ground Reaction Force Asymmetry (GRF), Push-off Force Asymmetry (POF), and Braking Force Asymmetry (BRK). Utilizing the Computer-Assisted Rehabilitation Environment (CAREN) with 18 participants, this research examines these interventions' effectiveness in generating asymmetric gait. While the results during adaptation indicate that BRK was significantly affected by both A-RAC (p = 0.
View Article and Find Full Text PDFThe synergistic effect of c-Myb hyperactivation and Pu.1 deficiency induces Pelger-Huët anomaly and promotes sAML.
Proc Natl Acad Sci U S A
March 2025
Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, China.
Approximately 30% of patients with myelodysplastic syndrome (MDS) progress to secondary acute myeloid leukemia (sAML) via accumulating gene mutations. Genomic analyses reveal a complex interplay among mutant genes, with co-occurring and mutually exclusive patterns. Hyperactivation of c-MYB and deficiency of PU.
View Article and Find Full Text PDFThe pathogenicity island 1-encoded small RNA InvR mediates post-transcriptional feedback control of the activator HilA in .
J Bacteriol
February 2025
Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Unlabelled: Pathogenicity Island 1 (SPI1) encodes a Type-3 secretion system (T3SS) essential for invasion of intestinal epithelial cells. Many environmental and regulatory signals control SPI1 gene expression, but in most cases, the molecular mechanisms remain unclear. Many regulatory signals control SPI1 at a post-transcriptional level, and we have identified a number of small RNAs (sRNAs) that control the SPI1 regulatory circuit.
View Article and Find Full Text PDFFluorescent Clade IIb Lineage B.1 Mpox Viruses for Antiviral Screening.
Viruses
February 2025
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid (UAM), 28049 Madrid, Spain.
The ongoing global outbreak of mpox caused by clade IIb viruses has led to more than 100,000 confirmed cases around the world, highlighting the urgent need for antiviral research to combat current and future mpox outbreaks. Reporter viruses expressing fluorescent proteins to monitor viral replication and virus spreading in cell culture provide a powerful tool for antiviral drug screening. In this work, we engineered two recombinant mpox clade IIb viruses by inserting, under the control of the vaccinia early/late promoter 7.
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