AI Article Synopsis
- Efficient methods were created to synthesize α-branched amines using innovative C-H functionalization techniques involving three and four components.
- A unique hydrazone directing group in the products allows easy transformation into several useful chemical functionalities, like nitriles and alkenes through different catalytic processes.
- This research marks the first instance of utilizing a four-component C-H functionalization reaction, expanding the capabilities in synthetic chemistry.
Article Abstract
Efficient syntheses of α-branched amines by three- and four-component C-H functionalization employing a diversifiable hydrazone directing group have been developed. The hydrazone in the α-branched amine products has been readily converted to multiple desirable functionalities such as a nitrile, a carboxylic acid, alkenes, and heterocycles using diverse heterolytic chemistry and homolytic transition metal- or photoredox-catalyzed processes. This study represents the first example of a four-component C-H functionalization reaction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785212 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.1c03807 | DOI Listing |
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