New hydroperoxycycloartane-complete chemical shifts assignment of C and H-and cytotoxicity evaluation of cycloartanes isolated from .

Nat Prod Res

Laboratório de Ciências Químicas, CCT, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, RJ, Brasil.

Published: November 2022

New cycloartane, 22-hydroxy-25-hydroperoxycycloart-23-en-3-one (), along with six known analogues () and three steroids (), were isolated from the leaves of . Structures were elucidated mainly on the basis of the analysis of 1D and 2D NMR (H and C) and HRESIMS spectroscopic data, involving comparison with data of the literature. The cytotoxic activities of and isolated compounds were also evaluated against human leukemia cell line Molt-4 (acute lymphoblastic) and exhibited good cytotoxic activity with IC values ranging from 10.62 to 21.14 μM.

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http://dx.doi.org/10.1080/14786419.2021.2013214DOI Listing

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