AI Article Synopsis
- In France, the mortality risk for children with type 1 diabetes (T1D) and the causes of death remain largely unknown, prompting a study to analyze mortality data from 1987 to 2016 for children aged 1-14 years.
- Out of 146 deaths linked to diabetes, 97 were specifically attributed to T1D, with diabetic ketoacidosis (DKA) being the leading cause of death at 58%.
- The study found that while standardized mortality ratios (SMRs) decreased over the years, children aged 1-4 still experienced significantly high mortality rates, indicating a critical need for improved diabetes management and early intervention for this age group.
Article Abstract
Background: Mortality risk for children with type 1 diabetes (T1D) is unknown in France and their causes of death are not well documented.
Aim: To determine the standardized mortality ratios (SMRs) and causes of death in children aged 1-14 years with T1D from 1987 to 2016.
Methods: The French Center for Epidemiology on Medical Causes of Death collected all death certificates in mainland France. SMRs, corrected SMRs (accounting for missing cases of deaths unrelated to diabetes), and 95% confidence intervals were calculated.
Results: Of 146 deaths with the contribution of diabetes, 97 were due to T1D. Mean age at death of the subjects with T1D was 8.8 ± 4.1 years (54% males). The cause of death was diabetic ketoacidosis (DKA) in 58% of the cases (70% in subjects 1-4 years), hypoglycemia or dead-in-bed syndrome in 4%, related to diabetes but not described in 24%, and unrelated to diabetes in 14%. The SMRs showed a significant decrease across the years, except for the 1-4 age group. In the last decade (2007-2016), the crude and corrected SMRs were significantly different from 1 in the 1-4 age group (5.4 [2.3; 10.7] and 6.1 [2.8; 11.5]), no longer significant in the 5-9 age group (1.7 [0.6; 4.0] and 2.1 [0.8; 4.5]) and borderline significant in the 10-14 age group (1.7 [0.8; 3.2] and 2.3 [1.2; 4.0]).
Conclusions: Children with T1D aged 1-4 years still had a high mortality rate. Their needs for early recognition and safe management of diabetes are not being met.
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| http://dx.doi.org/10.1111/pedi.13298 | DOI Listing |
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