AI Article Synopsis
- The study investigates the connection between the MYO9B gene variant rs962917 and inflammatory bowel disease (IBD) in the Guangxi Zhuang population.
- Researchers compared intestinal tissue samples from 153 IBD patients and 155 healthy controls, using DNA analysis techniques to focus on the rs962917 SNP.
- Results showed a significant difference in the genotype frequencies of the affected groups, suggesting that the MYO9B SNP rs962917 may influence Crohn's disease risk in this population.
Article Abstract
Objective: To analyze the correlation between site rs962917 of the MYO9B gene and inflammatory bowel disease (IBD) in the Guangxi Zhuang nationality population.
Methods: The intestinal mucosa tissue of 153 IBD subjects (Han and Zhuang patients only) in the Guangxi Zhuang autonomous region comprised the case group, and the intestinal mucosa tissue of 155 healthy subjects (Han and Zhuang patients only) in the same region represented the control group. Deoxyribonucleic acid was extracted from the intestinal mucosa tissue of each experimental group, and the MYO9B gene-target fragment containing the single nucleotide polymorphism (SNP) site rs962917 was designed. Finally, polymerase chain reaction products were obtained by amplification, analyzed, and compared using the sequencing results.
Results: The results indicated that the genotype frequency of the MYO9B SNP site rs962917 between Crohn's disease (CD) and control groups of Zhuang and Han participants differed significantly (P < 0.05). Furthermore, the genotype frequency of MYO9B site rs962917 differed significantly between the Zhuang and Han population groups (P < 0.05).
Conclusion: Site rs962917 of the MYO9B gene is related to CD susceptibility and incidence among the Guangxi Zhuang population.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8646109 | PMC |
| http://dx.doi.org/10.2147/IJGM.S338142 | DOI Listing |
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