AI Article Synopsis
- * Researchers sequenced samples from the first two waves of the pandemic in Senegal, identifying new combinations of spike mutations that were unique to the second wave.
- * The findings reveal ongoing local diversification of the virus and suggest that different lineages may be evolving escape mutations simultaneously.
Article Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages that carry mutations in the spike gene are of concern for potential impact to treatment and prevention efforts. To monitor for new SARS-CoV-2 mutations, a panel of specimens were sequenced from both wave one (N = 96), and wave two (N = 117) of the pandemic in Senegal by whole genome next generation sequencing. Amongst these genomes, new combinations of SARS-CoV-2 spike mutations were identified, with E484K + N501T, L452R + N501Y, and L452M + S477N exclusively found in second wave specimens. These sequences are evidence of local diversification over the course of the pandemic and parallel evolution of escape mutations in different lineages.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655062 | PMC |
| http://dx.doi.org/10.1038/s41598-021-02874-z | DOI Listing |
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