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Entactogen Effects of Ketamine: A Reverse-Translational Study.
Am J Psychiatry
September 2024
Department of Psychiatry (Hess, Hutchinson, Gould), Department of Neurobiology (Gould), and Department of Pharmacology (Gould), University of Maryland School of Medicine, Baltimore; Experimental Therapeutics and Pathophysiology Branch, NIMH, Bethesda, Md. (Greenstein, Zarate); Baltimore Veterans Affairs Medical Center, Veterans Affairs Maryland Health Care System, Baltimore (Gould).
Objective: The authors sought to assess the prosocial, entactogen effects of ketamine.
Methods: Pleasure from social situations was assessed in a sample of participants with treatment-resistant depression from randomized, double-blind, placebo-controlled studies, using four items of the Snaith-Hamilton Pleasure Scale (SHAPS) at five time points over 1 week following treatment with ketamine (0.5 mg/kg intravenously) or placebo.
Problematic substance use in depressed adolescents: Prevalence and clinical correlates.
Addict Behav Rep
June 2024
Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.
Background: Substance use among adolescents is common and associated with significant consequences, including depression. Adolescents can experience myriad problems related to early onset substance use and depression, making further understanding of this comorbidity necessary.
Method: Participants were a subset from a large-scale performance improvement project and consisted of adolescents aged 12-18 who screened positive for depression during their routine medical or psychiatric appointment and who then completed the substance use assessment Car, Relax, Alone, Forget, Friends, Trouble Version 2.
Survey of U.S. Residents and Their Usage of Electronic Cigarettes with Drugs Other Than Nicotine.
J Psychoactive Drugs
October 2024
Department of Forensic Science, Virginia Commonwealth University, Richmond, VA, USA.
Electronic cigarettes (e-cigs), originally intended to be used as cigarette substitutes, have evolved into discreet devices for consuming drugs other than nicotine (DOTNs). Presented are the results of an exploratory survey in which information regarding demographics, e-cig device type, DOTN use, frequency and context of use was collected. The average reported age of respondents was 27.
View Article and Find Full Text PDFFuturistic Thinking about Engineering "Geneospirituality" to Help Prevent Relapse of Reward Deficiency Syndrome (RDS) Behaviors.
EC Psychol Psychiatr
February 2023
Department of Psychiatry, Long School of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA.
It is with a saddened heart that we are dedicating this article to the loving memory of our dear departed friend and associate B. William Downs. Bill was well known in the nutritional space worldwide for his major contributions to the health and welfare of millions around the globe.
View Article and Find Full Text PDFThe novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
Transl Psychiatry
June 2023
Relmada Therapeutics, Coral Gables, FL, USA.
Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robust, and sustained antidepressant effects. Two studies were conducted to evaluate the abuse potential of esmethadone.
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