AI Article Synopsis
- The study focuses on synthesizing and analyzing twelve new compounds called 2-aryl(heteroaryl)-6-(4-alkyl(aryl)-1H-1,2,3-triazol-1-yl)-4-(trifluoromethyl)quinolines, using chemical reactions known as CuAAC to achieve high yields (77-95%).
- The structural characteristics of these compounds were thoroughly examined using various techniques, including NMR spectroscopy, X-ray diffraction, and HRMS.
- Additionally, the research evaluated their photophysical properties and biological interactions, specifically how they bind to DNA and human serum albumin, and compared these findings with similar compounds from recent studies.
Article Abstract
The synthesis, structural analysis, and evaluation of the photophysical properties of twelve novel 2-aryl(heteroaryl)-6-(4-alkyl(aryl)-1H-1,2,3-triazol-1-yl)-4-(trifluoromethyl)quinolines (6-8), where aryl(heteroaryl)=Ph, 4-Me-C H , 4-F-C H and 2- furyl; 4-alkyl(aryl)=-CH OH, -(CH ) CH and Ph, are reported. Hybrid scaffolds 6-8 were synthesized at 77-95 % yields by regioselective copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction of unpublished 6-azido-4-(trifluoromethyl)quinolines (2) with selected terminal alkynes (3-5). Azido intermediates 2 were obtained from the reaction of 6-amino-4-(trifluoromethyl)quinolines (1) and sodium azide at good yields (78-87 %). Compounds 6-8 were structurally fully characterized by H-, C- and F- and H- C 2D-NMR (HSQC, HMBC) spectroscopy, X-ray diffraction (SC-XRD) and HRMS analysis. Moreover, the photophysical properties, DNA- and HSA-binding experiments (bio-interactions), and molecular docking studies for compounds 6-8 were performed. These are discussed and compared with similar compounds from recent research.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbic.202100649 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Unraveling the Stoichiometric Interactions and Synergism between Ligand-Protected Gold Nanoparticles and Proteins.
J Am Chem Soc
January 2025
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117585, Singapore.
Nanomaterials that engage in well-defined and tunable interactions with proteins are pivotal for the development of advanced applications. Achieving a precise molecular-level understanding of nano-bio interactions is essential for establishing these interactions. However, such an understanding remains challenging and elusive.
View Article and Find Full Text PDFInfluence of branched ligand architectures on nanoparticle interactions with lipid bilayers.
Nanoscale
January 2025
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Gold nanoparticles functionalized with organic cationic ligands have shown promise as biomedical agents, but their interactions with cellular membranes are not yet well-understood and design rules for ligands that promote desired cellular interactions are lacking. Past experimental studies have demonstrated that ligand lipophilicity, quantified by the ligand end group partition coefficient, can be used as a descriptor for predicting nano-bio interactions, but such a descriptor is incapable accounting for ligand architecture, such as chain branching. To probe the effects of ligand end group architecture on ligand-lipid interactions, we perform molecular dynamics simulations to investigate how ligand alkyl chain branching modulates the thermodynamics and mechanisms of nanoparticle adsorption to lipid membranes.
View Article and Find Full Text PDFMolecular mechanism of IgE-mediated FcεRI activation.
Nature
January 2025
Research Center for Industries of the Future, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.
Allergic diseases affect more than a quarter of individuals in industrialized countries, and are a major public health concern. The high-affinity Fc receptor for immunoglobulin E (FcεRI), which is mainly present on mast cells and basophils, has a crucial role in allergic diseases. Monomeric immunoglobulin E (IgE) binding to FcεRI regulates mast cell survival, differentiation and maturation.
View Article and Find Full Text PDFCryoSeek: A strategy for bioentity discovery using cryoelectron microscopy.
Proc Natl Acad Sci U S A
October 2024
Beijing Frontier Research Center for Biological Structures, State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Article Synopsis
- Scientists are changing how they study proteins, moving from just figuring out their shapes to discovering new ones that they didn't know about before.
- They used a special technique called cryoelectron microscopy to look at tiny samples from a pond and found two similar protein structures called TLP-1a and TLP-1b.
- These proteins are unique and might be linked to unknown bacteria, helping researchers learn more about proteins and their functions.
Conformational Selection of α-Synuclein Tetramers at Biological Interfaces.
J Chem Inf Model
October 2024
Department of Physics, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland.
Controlling the polymorphic assemblies of α-synuclein (αS) oligomers is crucial to reroute toxic protein aggregation implicated in Parkinson's disease (PD). One potential mediator is the interaction of αS tetramers with cell membranes, which may regulate the dynamic balance between aggregation-prone disordered monomers and aggregation-resistant helical tetramers. Here, we model diverse tetramer-cell interactions and compare the structure-function relations at the supramolecular-biological interface with available experimental data.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!