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Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer.
Acta Pharm Sin B
November 2024
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
A colon-specific drug delivery system has great potential for the oral administration of colorectal cancer. However, the uncontrollable fate of liposomes makes their effectiveness for colonic location, and intratumoral accumulation remains unsatisfactory. Here, an oral colon-specific drug delivery system (CBS-CS@Lipo/Oxp/MTZ) was constructed by covalently conjugating spores (CBS) with drugs loaded chitosan (CS)-coated liposomes, where the model chemotherapy drug oxaliplatin (Oxp) and anti-anaerobic bacteria agent metronidazole (MTZ) were loaded.
View Article and Find Full Text PDFEstimating the Population-Level Impact of Empiric Anti-Anaerobic Antibiotics among US Adults Hospitalized with Sepsis.
Am J Respir Crit Care Med
November 2024
University of Michigan Health System, Internal Medicine, Ann Arbor, Michigan, United States.
Epidemiology and Outcomes of Recurrent Infection Among Hematopoietic Cell Transplant Recipients: A Single-center, Retrospective 10-year Study.
Open Forum Infect Dis
October 2024
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Article Synopsis
- * Among 3,479 HCT patients, 416 had an initial CDI, with a recurrence rate of 10% within 12 weeks; metronidazole monotherapy was linked to a higher risk of recurrence.
- * Results indicate that while only a small percentage required hospital admission after recurrence, no patients died within 30 days, highlighting the need for further research to understand the risk factors for recurrence and to improve treatment strategies.
Empirical antibiotic therapy for sepsis: save the anaerobic microbiota.
Lancet Respir Med
January 2025
Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands; Division of Infectious Diseases, Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Antibiotics are fundamental in sepsis management; however, the optimal empirical treatment remains debated. Despite anaerobes rarely being the causative pathogen of sepsis, antibiotics targeting them are frequently used, which might lead to unintended consequences. Multiple studies have shown that depletion of commensal anaerobic gut microbes by anti-anaerobic antibiotics influences systemic immunity and is associated with increased mortality in patients with sepsis.
View Article and Find Full Text PDFThird Kuwaiti Multicenter Survey of Antibiotic Susceptibility of Anaerobic Bacteria: A Comparative Analysis of 20-Year Data.
Microb Drug Resist
September 2024
Department of Microbiology, College of Medicine, Kuwait University, Safat, Kuwait.
This study aimed to evaluate antibiotic susceptibility and antimicrobial resistance trends among clinically significant anaerobes in Kuwait hospitals from 2013 to 2022, comparing these findings with data from 2002 to 2012. The study prospectively collected 2,317 anaerobic isolates from various body sites across four Kuwaiti hospitals between January 2013 and December 2022. The minimum inhibitory concentrations for 11 antianaerobic antibiotics were determined using E-test methodology.
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