AI Article Synopsis
- There is limited evidence regarding the traits of individuals with subjective cognitive decline (SCD) who also have amyloid positivity, which is related to Alzheimer's disease.
- A study of 1640 participants showed that factors like age, clinical setting, and the presence of the APOE ε4 gene are linked to higher amyloid positivity, whereas education level also plays a role.
- Specific SCD characteristics such as confirmed complaints and lack of depressive symptoms were associated with amyloid positivity, suggesting these traits can aid in identifying individuals who may have amyloid-related cognitive decline.
Article Abstract
Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited.
Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity.
Results: Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages.
Discussion: Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786747 | PMC |
| http://dx.doi.org/10.1002/alz.12512 | DOI Listing |
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