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| http://dx.doi.org/10.1016/j.jamda.2021.11.014 | DOI Listing |
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Real-time feedback on chest compression efficacy by hands-free carotid Doppler in a porcine model.
Resusc Plus
June 2024
Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway.
Aim: Current guidelines for cardiopulmonary resuscitation (CPR) recommend a one-size-fits-all approach in relation to the positioning of chest compressions. We recently developed RescueDoppler, a hands-free Doppler ultrasound device for continuous monitoring of carotid blood flow velocity during CPR. The aim of the present study is to investigate whether RescueDoppler via real-time hemodynamic feedback, could identify both optimal and suboptimal compression positions.
View Article and Find Full Text PDFIn need of age-appropriate cardiac models: Impact of cell age on extracellular matrix therapy outcomes.
Aging Cell
November 2023
Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana, USA.
Aging is the main risk factor for cardiovascular disease (CVD). As the world's population ages rapidly and CVD rates rise, there is a growing need for physiologically relevant models of aging hearts to better understand cardiac aging. Translational research relies heavily on young animal models; however, these models correspond to early ages in human life, therefore cannot fully capture the pathophysiology of age-related CVD.
View Article and Find Full Text PDFThe Survival of the Surviving Sepsis Campaign.
Med Clin North Am
November 2022
Department of Emergency Medicine, Medstar Washington Hospital Center, 110 Irving St, Washington, DC 20010, USA.
Even well-intentioned policies have great potential to cause harm. This statement is vividly illustrated by the influential, yet controversial, Surviving Sepsis Campaign guidelines and subsequent CMS benchmarks. Despite low-quality evidence, tendentious industry ties, and rebuke from the Infectious Disease Society of America (IDSA), these benchmarks continue to eschew therapy driven by clinician expertise and individual patient needs in favor of mandating an arbitrary, one-size-fits-all approach that suspends clinical judgment and promotes indiscriminate use of treatments that have the potential to cause great harm.
View Article and Find Full Text PDFCMS' One-Size-Fits-All Mandate on Vaccines for all Health Care Workers is a Bad Idea.
J Am Med Dir Assoc
January 2022
Bernardo Geriatrics & Home Care Newberry, SC, USA.
Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics.
J Mol Cell Cardiol
August 2020
Division of Cancer & Stem Cells, Biodiscovery Institute, University of Nottingham, NG7 2RD, UK. Electronic address:
Background: Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular condition. Despite being strongly associated with genetic alterations, wide variation of disease penetrance, expressivity and hallmarks of progression complicate treatment. We aimed to characterize different human isogenic cellular models of HCM bearing patient-relevant mutations to clarify genetic causation and disease mechanisms, hence facilitating the development of effective therapeutics.
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