AI Article Synopsis
- - Dyslipidemia is linked to fatty liver disease (FLD), and this study aimed to clarify the connection between remnant lipoprotein cholesterol (RLP-C) and FLD occurrence and severity.
- - The research analyzed data from over 38,000 health check participants, finding a strong dose-response relationship where higher RLP-C levels significantly increased FLD risk and severity, with an optimal RLP-C cut-off value of 0.45 mmol/L.
- - The findings suggest that RLP-C can be a useful marker for identifying individuals at risk of developing FLD, potentially guiding targeted interventions to reduce its prevalence.
Article Abstract
Context: Dyslipidemia is related to fatty liver disease (FLD), whose relationship with remnant lipoprotein cholesterol (RLP-C), a component of blood lipids, remains unclear.
Objective: To clarify the correlation between RLP-C and the occurrence and severity of FLD and establish an FLD discriminant model based on health check indicators.
Methods: Retrospective study of participants who underwent health check-up in the First Affiliated Hospital of China Medical University (Shenyang, China) between January and December 2019. We categorized participants according to liver ultrasound results and analyzed the correlation between RLP-C and occurrence of FLD (n = 38 885) through logistic regression, restricted cubic spline, and receiver operating characteristic curve. We categorized the severity of FLD according to the control attenuation parameter and analyzed the correlation between RLP-C and FLD severity through multiple logistic regression; only males were included (n = 564).
Results: The adjusted OR (aOR) per SD between RLP-C and FLD was 2.33 (95% CI 2.21-2.46, P < .001), indicating a dose-response relationship (P < .0001). The optimal cut-off value of RLP-C was 0.45 mmol/L and the area under the curve (AUC) was 0.79. The AUC of the 8-variable model was 0.89 in both the training and the validation sets. FLD severity was related to the level of RLP-C (aOR per SD = 1.29, 95% CI 1.07-1.55, P = .008).
Conclusion: RLP-C has a strong positive correlation with FLD occurrence and FLD severity. These results may help clinicians identify and implement interventions in individuals with high FLD risk and reduce FLD prevalence.
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| http://dx.doi.org/10.1210/clinem/dgab825 | DOI Listing |
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