AI Article Synopsis
- AGR2 is a small protein (20 kDa) crucial for oxidative protein folding in the endoplasmic reticulum and supports vital cell survival pathways.
- AGR2 was first identified in the African clawed frog and is important for embryonic development; it is often deregulated in cancer, influencing tumor initiation and progression.
- The review discusses AGR2’s known functions, its role in both embryonic and cancer development, and its potential as a tumor biomarker and target for cancer immunotherapy.
Article Abstract
Anterior gradient 2, AGR2, is a small, 20 kDa protein that plays a vital role in oxidative protein folding in the endoplasmic reticulum. AGR2 is involved in several signal transduction pathways that are essential for cell survival. It was initially discovered in the African clawed frog, , where it plays an important function in embryonic development. Akin to several other developmental genes, it is also frequently deregulated in cancer, where it plays a decisive role in tumor initiation, progression and metastasis. In this review, we have summarized currently known AGR2 functions, its expression and function in embryonic and cancer development, as well as its potential as a candidate tumor biomarker and promising new target for cancer immunotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8640830 | PMC |
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