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| http://dx.doi.org/10.1093/nsr/nwab167 | DOI Listing |
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Neuronal Imaging at 8-Bit Depth to Combine High Spatial and High Temporal Resolution With Acquisition Rates Up To 40 kHz.
J Biophotonics
January 2025
Univ. Grenoble Alpes, CNRS, LIPhy, Grenoble, France.
A challenge in neuroimaging is acquiring frame sequences at high temporal resolution from the largest possible number of pixels. Measuring 1%-10% fluorescence changes normally requires 12-bit or higher bit depth, constraining the frame size allowing imaging in the kHz range. We resolved Ca or membrane potential signals from cell populations or single neurons in brain slices by acquiring fluorescence at 8-bit depth and by binning pixels offline, achieving unprecedented frame sizes at kHz rates.
View Article and Find Full Text PDFLinking structural and rheological memory in disordered soft materials.
Soft Matter
January 2025
Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA.
Linking the macroscopic flow properties and nanoscopic structure is a fundamental challenge to understanding, predicting, and designing disordered soft materials. Under small stresses, these materials are soft solids, while larger loads can lead to yielding and the acquisition of plastic strain, which adds complexity to the task. In this work, we connect the transient structure and rheological memory of a colloidal gel under cyclic shearing across a range of amplitudes a generalized memory function using rheo-X-ray photon correlation spectroscopy (rheo-XPCS).
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Elife
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Eikon Therapeutics Inc, Hayward, United States.
The regulation of cell physiology depends largely upon interactions of functionally distinct proteins and cellular components. These interactions may be transient or long-lived, but often affect protein motion. Measurement of protein dynamics within a cellular environment, particularly while perturbing protein function with small molecules, may enable dissection of key interactions and facilitate drug discovery; however, current approaches are limited by throughput with respect to data acquisition and analysis.
View Article and Find Full Text PDFSerum glial fibrillary acidic protein in acute stroke: feasibility to determine stroke-type, timeline and tissue-impact.
Front Neurol
December 2024
Department of Neurosciences, University of Montreal, Montréal, QC, Canada.
Background: Interest is emerging regarding the role of blood biomarkers in acute stroke. The aim of this pilot study was to determine the feasibility of biomarker acquisition in suspected acute stroke, using modern ultrasensitive immunoassay techniques, and explore their potential usefulness for stroke diagnosis and management.
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Analyzing the Impact of Binaural Beats on Anxiety Levels by a New Method Based on Denoised Harmonic Subtraction and Transient Temporal Feature Extraction.
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Faculty of Electronics, Communication and Computers, Pitești University Center, National University of Science and Technology POLITEHNICA Bucharest, 110040 Pitesti, Romania.
Anxiety is a widespread mental health issue, and binaural beats have been explored as a potential non-invasive treatment. EEG data reveal changes in neural oscillation and connectivity linked to anxiety reduction; however, harmonics introduced during signal acquisition and processing often distort these findings. Existing methods struggle to effectively reduce harmonics and capture the fine-grained temporal dynamics of EEG signals, leading to inaccurate feature extraction.
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