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An expanding universe of mutational signatures and its rapid evolution in single-stranded RNA viruses.
Mol Biol Evol
January 2025
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
The study of mutational processes in somatic genomes has gained recent momentum, uncovering a wide array of endogenous and exogenous factors associated with somatic changes. However, the overall landscape of mutational processes in germline mutations across the tree of life and associated evolutionary driving forces are rather unclear. In this study, we analyzed mutational processes in single-stranded RNA (ssRNA) viruses which are known to jump between different hosts with divergent exogenous environments.
View Article and Find Full Text PDFBiosynthesis of Zinc Oxide Nanoparticles Using Dried Leaves of Camellia sinensis: Methods to Characterize and Assess Their Effects on Mesenchymal Stem Cell Viability.
Methods Mol Biol
January 2025
Department of Food Quality Control and Analysis, Vocational School of Health Services, Istanbul Gelisim University, Avcılar, Istanbul, Turkey.
Stem cell nanotechnology (SCN) is an important scientific field to guide stem cell-based research of nanoparticles. Currently, nanoparticles (NPs) have a rich spectrum regarding the sources from which they are obtained (metallic, polymeric, etc.), the methods of obtaining them (physical, chemical, biological), and their shape, size, electrical charge, etc.
View Article and Find Full Text PDFA 19-year-old asymptomatic woman.
Retin Cases Brief Rep
January 2025
New England Eye Center, Tufts Medical Center, Boston, MA.
Purpose: To describe a case of stellate multiform amelanotic choroidopathy (SMACH) with focal hyperfluorescence on indocyanine green angiography (ICGA).
Methods: Case report.
Results: A 19-year-old Caucasian woman was seen for an asymptomatic choroidal lesion.
Investigative genetic genealogy practices warranting policy attention: Results of a modified policy Delphi.
PLoS Genet
January 2025
Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, United States of America.
A technique known as investigative genetic genealogy (IGG) was first introduced to criminal investigations in 2018, and it has since been used by U.S. law enforcement to help identify hundreds of criminal perpetrators and unidentified human remains.
View Article and Find Full Text PDFThe Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions.
Nat Commun
January 2025
Epigenetics and Immune Disease Group, Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Spain.
Dysregulated microglia activation, leading to neuroinflammation, is crucial in neurodegenerative disease development and progression. We constructed an atlas of human brain immune cells by integrating nineteen single-nucleus RNA-seq and single-cell RNA-seq datasets from multiple neurodegenerative conditions, comprising 241 samples from patients with Alzheimer's disease, autism spectrum disorder, epilepsy, multiple sclerosis, Lewy body diseases, COVID-19, and healthy controls. The integrated Human Microglia Atlas (HuMicA) included 90,716 nuclei/cells and revealed nine populations distributed across all conditions.
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