Background: The total naso-ocular symptom score (TSS) is widely used as an endpoint to evaluate the severity of seasonal allergic rhinitis. However, it is not a generic preference-based measure. We sought to develop an algorithm for mapping between the TSS and health utility in Japanese cedar pollinosis (JCP). We also performed a cost-utility analysis of sublingual immunotherapy (SLIT) for JCP by using this algorithm.
Methods: Patients with JCP filled out the TSS questionnaire and EQ-5D-5L simultaneously during the pollen season in 2019 and in 2020. We estimated a direct utility mapping model by regressing responses to individual TSS questions directly onto utility. The incremental cost-effectiveness ratio (ICER) of active SLIT to a placebo was determined by examining the drug expense and the estimated quality-adjusted life year (QALY) using a dataset from a double-blind placebo-controlled clinical trial.
Results: A total of 238 records were included for analysis. The estimated utility decreased with increasing severity of rhinitis. Patients with comorbid asthma showed lower utility. A negative and significant correlation was seen between the TSS and utility in both 2019 and 2020. The estimated equations were: Y(utility) = -0.0161∗X(TSS) + 1.005 in non-asthmatic JCP patients. The ICER of active SLIT to the placebo was estimated to be 4,049,720 and 6,011,218 JPY/QALY in the first and second year, respectively.
Conclusions: It is possible to reasonably predict utility from the total naso-ocular symptom score by using regression models. In the estimated algorithm, pre-seasonal SLIT for JCP is cost-effective.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.alit.2021.11.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Subacute onset rhino-orbital mucormycosis caused by Cunninghamella in a Chinese leukemia patient: A case report and literature review.
Eur J Ophthalmol
November 2024
Department of Ophthalmology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, P.R. China.
Article Synopsis
- - A case of rhino-orbital mucormycosis (ROM) caused by the rare and lethal fungus Cunninghamella was reported in a 50-year-old woman with acute leukemia in China, marking the first instance of this specific infection in the country.
- - After undergoing two chemotherapy cycles, the patient developed severe naso-ocular symptoms along with black necrosis on her eyelids, leading to the diagnosis of ROM through tissue biopsy and multidisciplinary consultation.
- - Even though Cunninghamella infections carry a high mortality rate, the patient's life was saved by adjusting antifungal treatment and timely surgery, highlighting the importance of early detection for better outcomes.
Successful Omalizumab Treatment of Rhinogenic Contact Point Headache Complicated by Severe Cedar Pollinosis: A Case Report.
Cureus
December 2023
Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Showa University, Tokyo, JPN.
Headache is one of the most common neurological disorders in children. The most common headache in children is a primary headache, including migraine and tension-type headache, but note that secondary headaches should be differentiated as a cause of headache in pediatric patients. The management of cedar pollinosis in pediatric patients is important because it can cause quality-of-life deficits in addition to nasal and ocular symptoms.
View Article and Find Full Text PDFAspirin challenge and desensitization in patients with suspected AERD in Qatar.
Qatar Med J
March 2022
Allergy and Immunology Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar E-mail:
Background: Aspirin-exacerbated respiratory disease (AERD) is a chronic disease characterized by chronic rhinosinusitis, nasal polyposis, asthma, and intolerance to nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin challenge is considered the gold standard for diagnosing AERD. Many patients with AERD have reported clinical benefits when desensitized to aspirin and maintained on daily aspirin therapy.
View Article and Find Full Text PDFMapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis.
Allergol Int
April 2022
Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan; Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Electronic address:
Background: The total naso-ocular symptom score (TSS) is widely used as an endpoint to evaluate the severity of seasonal allergic rhinitis. However, it is not a generic preference-based measure. We sought to develop an algorithm for mapping between the TSS and health utility in Japanese cedar pollinosis (JCP).
View Article and Find Full Text PDFNaso-ocular neuropeptide interactions in allergic rhinoconjunctivitis, rhinitis, and conjunctivitis.
World Allergy Organ J
May 2021
Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730, China.
Background: Ocular as well as nasal symptoms contribute to allergic response but remain poorly characterized. The aim of this study was to analyze the levels of substance P (SP), vasoactive intestinal peptide (VIP), and calcitonin gene-related peptide (CGRP) in tears and nasal secretions of patients with allergic rhinoconjunctivitis (ARC), allergic rhinitis, and allergic conjunctivitis, while exploring possible mechanisms of naso-ocular interactions.
Methods: A total of 21 patients with ARC, 17 with allergic rhinitis, 13 with allergic conjunctivitis, and 15 healthy controls were enrolled in the study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!