Introduction: Pleural fluid effusion is a possible harmful effect of sodium valproate. It most often consists in polynuclear eosinophilic pleurisy and occurs within months of treatment initiation.
Case Report: We report on a case of sodium valproate-induced pleural effusion occurring more than 12years after initiation of treatment. The original formula was variegated and not eosinophilic. The patient exhibited contralateral recurrence with continued treatment. Once treatment was discontinued, there was no recurrence during three-year follow-up.
Conclusion: Sodium valproate-induced pleural effusion can present an atypical polymorphous picture leading to erroneous diagnoses.
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[Sodium valproate-induced pleural effusion: When it changes sides!].
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Introduction: Pleural fluid effusion is a possible harmful effect of sodium valproate. It most often consists in polynuclear eosinophilic pleurisy and occurs within months of treatment initiation.
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Clinical and pathophysiological characteristics of valproate-induced pleural effusion.
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Experimental Research Center ELPEN, ELPEN Pharmaceuticals, Pikermi, Greece.
Article Synopsis
- Valproic acid is often used to treat seizure disorders and manic episodes but has been linked to valproate-induced pleural effusion, a condition with an unclear mechanism.
- The study aimed to analyze cases of pleural effusion related to valproate use, categorizing them by clinical features and types of immune response.
- The majority of identified cases (60.7%) involved exudative eosinophilic pleural effusion, indicating a possible hypersensitivity reaction or inflammation caused by the medication.
Fungal pleural effusion secondary to a rare cause of pancreatic pseudocyst.
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Department of Respiratory Paediatrics, Royal Brompton Hospital, London, UK.
We report a case of fungal pleural effusion secondary to presumed valproate induced pancreatitis with pseudocyst and stricture formation. A child with dyskinetic cerebral palsy who had been on sodium valproate for several years was transferred for drainage of a left sided pleural effusion. Pleural fluid culture consistently grew Candida glabrata although the patient was treated with broad-spectrum antibiotic and antifungal therapy.
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